Bradford Biology
Biology · IB Diploma · Opening Lab

Measure what you can't see.

A strip of red onion skin under the lens. Add salt water, wait two minutes, and the colour shrinks back from every cell wall. From that retreat, and a ruler you build inside the eyepiece, you can work out the concentration sealed inside the cell.

A companion to the lab, not the method sheet. Work through the first half before you reach the bench to build the idea; run the practical from your worksheet; then come back to the last stretch to make sense of your data.

Download the worksheet PDF →

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One · The Instrument

Magnification is just multiplication.

Two lenses sit between your eye and the cell. The eyepiece magnifies ten times. The objective you swing into place magnifies another forty.

Multiply them. Ten times forty is four hundred, the cell arrives four hundred times larger than life.

But four hundred times what? The view carries no scale until you give it one.

So you drop a tiny ruler into the eyepiece, the graticule, and teach it real units by lining it up against a stage micrometer. Calibrate once, and every cell after that can be measured.

Two · The Light Path

Drag each part to the right place.

Three parts decide how large the cell looks, and let you measure it. Match each label to where it sits.

drop label
drop label
drop label
Eyepiece × 10
Objective × 40
Stage + slide
Three · Read the Scale

Now give the ruler real units.

Calibrated at ×400, one eyepiece division is worth 2.5 µm, found by lining 100 divisions against the stage micrometer's 250 µm.

Drag the two markers to the edges of the cell, then read its width. Width = divisions × 2.5 µm.

010203040
Reading:, divisions
Four · A Prediction

Same onion. Two baths.

One strip rests in pure water. The other sits in salt water far stronger than the cell. Two minutes pass.

Slide A · the view
Pure water · 0.00 M
Slide B · the view
Strong salt · 1.00 M

In the salt bath, which way does water move, and why?

The reveal

Out, down its own gradient. Water isn't pulled, and it isn't trying to fix anything, it moves from where free water is plentiful, inside the cell, to where it is scarcer, in the salty solution outside.

If you've ever salted a cucumber and watched beads of water rise to the surface, you have already run this experiment.

IB exam tip: A question that asks you to explain this wants the direction and the mechanism, solute lowers water potential, so water diffuses to the lower value. A question that asks you to state it only wants the direction.

Five · Across the Membrane

Water crosses. The salt stays put.

The membrane lets water through but holds back salt. So water drifts to the side where it is scarcer, toward the salt.

Press play and watch the net flow build. Water moves; the solute can't follow.

Cell contents · dilute Salt solution · concentrated
Left water:, · right water:,
water salt (solute) pore in the membrane
Six · The Gradient

Watch the protoplast retreat.

Water potential is just how freely water can move. Add solute and you lower it. Water always flows toward the lower value.

Raise the outside concentration and watch the living contents pull away from the wall. Drag the slider.

One onion cell
0.0 M0.5 M1.0 M
Outside conc
0.00 M
Net water flow
Slightly in
Cell state
Turgid
Seven · Inside the Cell

The wall stays. The membrane lets go.

The cell wall is rigid scaffolding. It holds its shape when water leaves, it does not shrink.

What shrinks is the living part: the plasma membrane and everything it encloses. It peels inward, and the space behind it fills with the solution from outside.

That separation has a name, plasmolysis. It is the visible proof that water has left the cell.

Eight · The Plasmolysed Cell

Name the three things you can now see.

Water has left this cell. Drag each label to the part it points to.

drop label
drop label
drop label
Cell wall
Plasma membrane
Trapped solution
Nine · From Pictures to a Number

Half the cells tell you the answer.

Bathe strips of onion across a range of concentrations. In each, count what fraction of cells have plasmolysed.

Plot fraction against concentration. The curve climbs from almost none to almost all.

Find where exactly half have gone. There, the solution outside matches the cell inside, so that concentration is the one you couldn't see.

% plasmolysed vs external concentration
At the bench

Now run the practical.

Take your lab worksheet, prepare the mounts, calibrate the graticule for real, and gather your numbers. When you have your data, come back for the last stretch.

Ten · Exam-Style Question
Data-based question [6 marks]

A student bathed strips of red onion epidermis in sodium chloride solutions and recorded the percentage of plasmolysed cells in each. Cells were viewed with a ×10 eyepiece and a ×40 objective. The student found that 50% of cells were plasmolysed at a concentration of 0.30 mol dm⁻³.

  1. (a) State the total magnification used to view the cells. [1]
  2. (b) Outline how a stage micrometer is used to find the real width of one cell. [2]
  3. (c) Deduce what the 0.30 mol dm⁻³ result shows about the cell contents, and explain why the point at which 50% of cells are plasmolysed is used, rather than 100%. [3]
(a) State, 1 mark

STATE = a specific answer, no working needed. Award 1 mark.

  • ×400 / 400× (eyepiece ×10 multiplied by objective ×40) [1]
(b) Outline, 2 marks

OUTLINE = a brief account of the main steps. Award 1 mark per point, max 2.

  • line up the eyepiece graticule against the stage micrometer / known scale [1]
  • work out how many micrometres one graticule division represents (the calibration) [1]
  • measure the cell in graticule divisions, then convert to micrometres using the calibration [1]

Accept: "calibrate the graticule, then measure". Do not accept: using a ruler at high power / measuring without calibration.

(c) Deduce / Explain, 3 marks

DEDUCE = reach a conclusion from the data. EXPLAIN = give a reason. Award 1 mark per point, max 3.

  • the internal (solute) concentration of the cell is about 0.30 mol dm⁻³ [1]
  • at this concentration the solution is isotonic with the cells / there is no net movement of water [1]
  • cells vary, so at the isotonic point about half are above and half below / about half show plasmolysis [1]
  • 50% is a reliable midpoint to read from the curve, whereas 100% depends on the most resistant cells [1]

Accept: "water potential of cell ≈ water potential of 0.30 mol dm⁻³ solution". Do not accept: "the cell is 0.30 M of salt" without reference to internal concentration.

Eleven · Say It Back

Try saying it back.

Fill in the blanks. Stuck? Tap Reveal answers.

Osmosis is the net movement of down a gradient of water , across a partially permeable . When a plant cell in a strong solution loses water, its membrane peels from the wall, called . The outside concentration that plasmolyses half the cells matches the cell's own contents: its point.

Twelve · The Takeaway

You read the inside by watching the outside.

Plasmolysis turns a concentration you can't see into a number you can measure.

Magnification

Eyepiece times objective. Ten times forty is four hundred, and the calibrated graticule turns that into real micrometres.

IB: State = ×400. Explain = ×10 eyepiece × ×40 objective, scaled to µm via the graticule.

Water potential

Water moves down its own gradient, never pulled. Solute lowers the potential; water leaves toward the lower value.

IB: State = water moves out. Explain = solute lowers water potential, so water diffuses to the lower value.

The 50% point

Where half the cells plasmolyse, outside matches inside. That concentration is the cell's own.

IB: Deduce = internal conc ≈ that solution. Explain = isotonic, no net water movement.