Biology by Bradford · IB Biology HL · C2.2

Action
Potentials

How a charged membrane becomes a message — the spark, the wave, and the leap across the gap.

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01 · The resting potential

A neuron at rest is
quietly charged.

The value

A resting neuron sits at about −70 mV — the inside is more negative than the outside.

The pump

The Na⁺/K⁺ pump uses ATP to push 3 Na⁺ out for every 2 K⁺ in, building the gradients.

The leak

K⁺ leaks back out and large negative proteins stay trapped inside — so the inside stays negative.

02 · Anatomy of a neuron

Built to carry
a signal.

Tap a part of the neuron to see what it does.

Neuron

Tap a part on the left, or a button, to see its role.

03 · The action potential

Fire the
spike.

Hit Fire to sweep the impulse in real time — or drag along the trace to inspect any moment. Watch the Na⁺ and K⁺ channels open and close. Then switch the stimulus to test all-or-nothing.

+30 0 −55 −70 time →
← drag the trace to scrub
−70 mVResting

The Na⁺/K⁺ pump keeps the inside at about −70 mV. Voltage-gated channels are closed.

Na⁺ channel (voltage-gated)Closed
K⁺ channel (voltage-gated)Closed
04 · Across the synapse

From electrical
to chemical.

At the gap, the signal becomes a molecule. Tap each step.

Tap a step

The synapse converts an electrical impulse into a chemical signal, then back again.

Want the full detail — Ca²⁺ influx, exocytosis, receptor binding, and ACh recycling? See the Synaptic Transmission deep dive.

05 · Speed & signal type

Faster, and
two-way.

Saltatory conduction

Myelin insulates the axon, so depolarisation only happens at the nodes of Ranvier. The impulse jumps node to node — much faster.

What sets the speed

Conduction is faster with more myelin, a wider axon, and a higher temperature — up to ~120 m/s.

Excitatory vs inhibitory

Excitatory neurotransmitters depolarise (EPSP, toward threshold); inhibitory ones hyperpolarise (IPSP, away from threshold).

A neuron sums all its inputs — only if the total reaches threshold does it fire (all-or-nothing).

06 · The bigger picture

From stimulus
to response.

Every piece you've met is one link in a chain. Tap a concept to light up how it connects.

sits at fires an depolarises reaches threshold arrives at releases triggers Stimulus Neuron Resting potential Action potential Synapse Neurotransmitter Response
The signalling chain

A signal begins as a stimulus, becomes an electrical spike in a neuron, crosses the synapse as a chemical neurotransmitter, and ends as a response. Tap a concept to trace how it connects.

Tap any concept to trace its connections · tap the background to reset

07 · Your turn

Fill in
the gaps.

Drag each term into the gap it belongs in. Two terms are traps — they fit nowhere.

Placed: 0 / 10
Resting potential is aboutdrop
…maintained by thedrop
Threshold potential is aboutdrop
Na⁺ entering the cell causesdrop
K⁺ leaving the cell causesdrop
The impulse travels along thedrop
Gaps in the myelin are the nodes ofdrop
Jumping between nodes isdrop
Across the synapse the signal is adrop
Ca²⁺ triggers vesicle release bydrop
08 · Check yourself

HL-style
multiple choice.

Single best answer, Paper 1 style. Pick one — you'll see why.

Score: 0 / 7